Journal article
A. Vilgelm, C. Johnson, Nripesh Prasad, Jinming Yang, Sheau-Chiann Chen, G. Ayers, J. Sosman, J. Ecsedy, Shyr Yu, S. Levy, A. Richmond
2016
2016
Semantic Scholar
DOI
Cite
Cite
APA
Click to copy
Vilgelm, A., Johnson, C., Prasad, N., Yang, J., Chen, S.-C., Ayers, G., … Richmond, A. (2016). Abstract 5126: The link between therapy-induced senescence and anti-tumor immune microenvironment in melanoma.
Chicago/Turabian
Click to copy
Vilgelm, A., C. Johnson, Nripesh Prasad, Jinming Yang, Sheau-Chiann Chen, G. Ayers, J. Sosman, et al. “Abstract 5126: The Link between Therapy-Induced Senescence and Anti-Tumor Immune Microenvironment in Melanoma” (2016).
MLA
Click to copy
Vilgelm, A., et al. Abstract 5126: The Link between Therapy-Induced Senescence and Anti-Tumor Immune Microenvironment in Melanoma. 2016.
BibTeX Click to copy
@article{a2016a,
title = {Abstract 5126: The link between therapy-induced senescence and anti-tumor immune microenvironment in melanoma},
year = {2016},
author = {Vilgelm, A. and Johnson, C. and Prasad, Nripesh and Yang, Jinming and Chen, Sheau-Chiann and Ayers, G. and Sosman, J. and Ecsedy, J. and Yu, Shyr and Levy, S. and Richmond, A.}
}
Abstract
Tumor cell senescence is often induced by cancer therapeutics. Senescent cells secrete many proteins that may affect both malignant and non-malignant components of the tumor. The goal of this study was to determine how therapy-induced senescence (TIS) affects the immune microenvironment in melanoma. We used inhibitors of cell cycle kinases AURKA and CDK4/6 (AURKAi, CDK4/6i) to induce senescence in melanoma tumors. RNA sequencing analysis of AURKAi-treated syngeneic mouse tumors demonstrated that response to AURKA inhibition was strongly associated with induction of an immune transcriptome (p = 3.5E-29). Immunofluorescent staining and flow cytometric analysis of digested tumors showed correlation between the numbers of tumor-infiltrating leukocytes (TILs) and AURKAi response (Spearman r = -0.87, p Citation Format: Anna E. Vilgelm, C Andrew Johnson, Nripesh Prasad, Jinming Yang, Sheau-Chiann Chen, Gregory D. Ayers, Jeffrey A. Sosman, Jeffrey A. Ecsedy, Shyr Yu, Shawn E. Levy, Ann Richmond. The link between therapy-induced senescence and anti-tumor immune microenvironment in melanoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5126.