Journal article
A. Vilgelm, A. Richmond
Oncoimmunology, 2015
Oncoimmunology, 2015
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DOI
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APA
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Vilgelm, A., & Richmond, A. (2015). Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses. Oncoimmunology.
Chicago/Turabian
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Vilgelm, A., and A. Richmond. “Combined Therapies That Induce Senescence and Stabilize p53 Block Melanoma Growth and Prompt Antitumor Immune Responses.” Oncoimmunology (2015).
MLA
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Vilgelm, A., and A. Richmond. “Combined Therapies That Induce Senescence and Stabilize p53 Block Melanoma Growth and Prompt Antitumor Immune Responses.” Oncoimmunology, 2015.
BibTeX Click to copy
@article{a2015a,
title = {Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses},
year = {2015},
journal = {Oncoimmunology},
author = {Vilgelm, A. and Richmond, A.}
}
Abstract
We recently demonstrated that dual therapy combining AURKA and MDM2 antagonists is effective against melanoma in preclinical settings. Notably, besides inducing apoptosis, this regimen led to tumor senescence and stimulated the host's antitumor immune defenses. Treatments leveraging both cancer cell-intrinsic and extrinsic antitumor mechanisms can improve melanoma therapeutic outcomes.
